In 2020, BC RESURECT was successful in attaining a UBC Grant for Catalyzing Research Clusters. This provided the opportunity to create CanSAVE: Canadians Saving Arrest Victims Everywhere to spearhead innovative, national research collaborations with the goal of transforming the response to sudden cardiac arrest and dramatically improving survival. Our grand challenge is to further increase survival rates across Canada by focusing on 3 critical links in the chain of survival that are ripe for transformation: Improving recognition of sudden cardiac arrest; reducing response times for CPR and defibrillation prior to paramedic arrival; improving brain protection and brain recovery, and helping survivors live their best lives. To meet this challenge CanSAVE is helping lead national collaboration efforts and research in biosensor development, optimizing dispatcher recognition of sudden cardiac arrest, community volunteer response, drone AED delivery, treatments for neurologic recovery, bystander engagement programs and improving quality of life for survivors of sudden cardiac arrest.